Gonzalez drove in six runs in Colorado's big offensive night that pounded Arizona's staff. Starter Shelby Miller (0-4) allowed five runs before leaving after the first with right elbow tightness. With the game out of hand, the Diamondbacks turned to second baseman Daniel Descalso and catcher Alex Avila to pitch. Descalso tossed 2 2/3 innings in his fifth relief appearance. Avila threw two scoreless innings in his first time pitching.
Colorado scored seven runs off Jorge De La Rosa and four more off Yoshihisa Hirano to bring on Descalso in the fourth. He had retired the first nine batters he faced his career but Nolan Arenado greeted him with an RBI single and Gonzalez followed with a two-run homer. Descalso was the first position player in franchise history to pitch more than one inning. Avila became the second.
Charlie Blackmon and Ian Desmond also homered as Colorado ended a nine-game home losing streak to the Diamondbacks.
Marquez (8-8), who pitched six innings, hit his first career home run off Descalaso that made it 19-1. The 19 runs were the most this season for Colorado and one short of the franchise best.
Diamondbacks: Reliever TJ McFarland left the game in the fourth inning with neck tightness. ... Manager Torey Lovullo said OF Jarrod Dyson (right groin strain) is dealing with the break up of scar tissue related to his 2017 hernia surgery and said the team will keep him off his feet until after the break.
Rockies: RHP Bryan Shaw was activated from the 10-day DL and LHP Jerry Vasto optioned to Triple-A Albuquerque. Shaw pitched a scoreless ninth inning in his first appearance since June 23rd.
The Diamondbacks released RHP Fernando Salas a few days after designating him for assignment.
Diamondbacks RHP Shelby Miller (0-3, 9.00) makes his fourth start Wednesday since returning from Tommy John surgery. He will face Colorado RHP German Marquez (7-8, 4.92), who is 2-0 with a 1.29 ERA with 14 strikeouts and no walks in his last two starts.